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KMID : 0357920140480060409
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Korean Journal of Pathology
2014 Volume.48 No. 6 p.409 ~ p.412
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Hybrid Granular Cell Tumor/Perineurioma
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Kim Sung-Sun
Choi Yoo-Duk
Lee Jae-Hyuk
Choi Chan
Park Chang-Soo
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Abstract
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Hybrid peripheral nerve sheath tumors (PNSTs), which show hybrid features of more than one cell type normally found in a peripheral nerve sheath, are recently recognized clinical entities. Various composite tumors have been reported; however, granularcell tumor/perineurioma is a rare combination.1-4 Since perineurial cells may be found in other types of PNSTs, it is important to determine if those are reactive, remnantal, or true neoplastic when a perineurial component of the PNST is identified. Main differential diagnoses include granular perineurioma and granular cell tumor with reactive perineurial cell hyperplasia, which show a lack of immunopositivity for S-100 in the granular cells and prominent perineurial cell proliferation throughout the tumor, respectively.
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